Policy issues around computer-based methods as alternatives to animal testing
The short questionnaire is our invitation to policy makers, industry managers, educators, political leaders, NGOs, investors, citizens and all others who are not specialists in toxicology to comment on some of the issues that are raised and/or addressed by computer-based (in silico) methods.
We really hope you can take a few minutes to complete it. Please also email the link to others who may be interested.
- You can immediately complete it online (preferable method)
or download the questionnaire in PDF form and
- fill and send it to email@example.com
- or fill and fax it to Dr. Emilio Benfenati, 0039-02-39014735
- or fill and post it to Dr. Emilio Benfenati, Mario Negri Institute, Via Giuseppe La Masa 19, 20156, Milano, Italy
The purpose of survey
In recent years the EU has funded research into developing computer-based methods for evaluating the toxicity of chemicals, called ‘in silico methods’. These are potentially important in making it possible to test large numbers of chemicals (as required by the EU REACH legislation) while also reducing the numbers of tests on animals.
The ORCHESTRA project is funded by the EU to communicate some of those research findings. Our intention is to increase the understanding of these alternative methods among potential users in industry, among regulators and other decision-makers, and in the wider public and policy debates. This survey will help us to find out what people regard as the priorities, as well as what information is needed and how we should communicate it.
(There is a parallel questionnaire specifically for regulators, industry specialists, toxicologists, QSAR developers, scientists and any others with specialist knowledge or experience. If you would like to complete that questionnaire, or both, please do so.)
Several platforms of QSAR models exist. The ANTARES project lists hundreds of QSAR models, tens of them are freely available.
Some well known platforms are:
VEGA: The ORCHESTRA project, with ANTARES, has developed the VEGA platform, which incorporates CAESAR and T.E.S.T. models into a single framework. An advantage of the VEGA platform is the facilitated and supported user-access: supporting information, tutorials and videos are all available on the web site. It has been developed from the point of view of the user, and of the REACH requirements. Each model produces not only a predicted value, but also many pages of explanation and assessment of its reliability.
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