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QSARs in REACH? - Uses, issues and priorities

A video documentary in four parts, based on interviews
with regulators, industry and QSAR developers.

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ORCHESTRA Workshop: REACH and QSAR - What can we learn from case studies?

Milan, 6 April, 2011

View the report on the outcomes

Help to guide our work - respond to a short survey

technical survey - on your experience and view of computer-based methods in toxicology
public survey - on reducing animal testing and other issues.

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21st ANNUAL MEETING - SETAC EUROPE

ECOSYSTEM PROTECTION IN A SUSTAINABLE WORLD
a Challenge for Science and Regulation
15 - 19 May 2011, Milan, Italy

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Introductory leaflet on in-silico methods

for people who want to know about in-silico methods
and/or to understand what the ORCHESTRA project is about

Download the leaflet

ORCHESTRA

Regulatory Context

INTRODUCTORY LEAFLET

A concise and accessible explanation of in silico methods and the issues around them, for people who want to know about them, and/or want to understand what the ORCHESTRA project is about. Download the leaflet

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The REACH legislation

In December 2006 the European Community adopted a new regulation addresses the production circulation of chemical substances in the European territory, and their potential impacts on both human health and the environment. This new regulation is called REACH (Registration, Evaluation, Authorisation and restriction of Chemicals) and states that for each chemical circulating in the European territory, a complete dossier on physico-chemical, biological and toxicological properties has to be compiled. In order to prevent an over-usage of animal testing, REACH regulation foresees and promotes the use of alternative methods (such as QSAR) stating that:

Before new tests are carried out to determine the properties listed in this Annex, all available in vitro data, in vivo data, historical human data, data from valid (Q)SARs and data from structurally related substances (read-across approach) shall be assessed first.

For more info refer to the REACH regulation ANNEX VII.
Click here to access the full text of the REACH legislation, available through the European Chemicals Agency (ECA) website.