The five ORCHESTRA platform presentations at the SETAC Europe 2011 conference in Milan can now be viewed in full below. The presentations address key aspects of QSAR models and their regulatory use.
Videos include: PowerPoint slides + speaker + event images + Q&A session.
How to improve the safe use, explanation and acceptance of QSAR models for REACH?
Emilio Benfenati (18 mins)
New QSAR models for regulatory purposes
Giuseppina Gini (27 mins)
Survey on Stakeholder Perceptions of Benefits and Barriers to the Use of In Silico Methods: Reflections on Regulatory Aspects.
Claire Mays, Emilio Benfenati, Simon Pardoe, Ralf Knauf. (13 mins)
How can the cautious policy of acceptance 'case-by-case' become a mechanism of progress towards the rigorous, successful and extensive use of QSARs within REACH?
Simon Pardoe, Emilio Benfenati, Giuseppina Gini, Claire Mays. (25 mins)
And from the Antares project:
The development of new tools towards a better exploitation of non-testing methods for regulatory purposes.
Alessandra Roncaglioni, Manganaro, A., Gonella Diaza, R., Lombardo, A., Petoumenou, M., Benfenati, E. (27 mins)
A brief visual overview of the ORCHESTRA booth and presentations at SETAC Europe 2011 is available here.
Presentations and views of the conference were filmed with advance permission from SETAC. Filmed and produced by PublicSpace Research Communication, as part of the EC FP7 ORCHESTRA dissemination project.
the use of QSAR models is an important example of in silico methods. Quantitative Structure- Activity Relationship models correlate the properties and molecular structure of a chemical with its biological effect on human health and/or on relevant species in an ecosystem. The correlation can then be used in the prediction and assessment of new substances. QSAR / in silico methods are applicable to organic (carbon-based) compounds, not to inorganic substances.
REACH
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the European regulation for the Registration, Evaluation, Authorisation and Restriction of Chemicals. It replaced nearly forty previous EU directives and regulations with a single regulation that makes manufacturers and importers responsible for registering chemicals with the European Chemicals Agency (ECHA), as well as for understanding and managing the risks associated with their use. REACH also aims to promote the use of existing data, and of alternative methods of assessment, such as QSAR methods.
Stakeholder
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professionals, organisations and citizens who are affected by an action or decision, and/or can affect it, and so have an interest or ‘stake’ in it. As citizens we are all stakeholders in chemical testing because we are affected by the quality of that testing. Regulators, researchers and users are particular kinds of stakeholders who may inform debate in the public interest or their institutional interest.
Related FAQ
What is ORCHESTRA?
ORCHESTRA is an EU project, funded to disseminate recent research on computer-based in silico methods for evaluating the toxicity of chemicals.
•• In silico methods make it possible to test large numbers of chemicals (as required by EU REACH legislation) while reducing the numbers of tests on animals.
The aim of the project is therefore to promote wider understanding, awareness and appropriate use of in silico methods.
Part of the ORCHESTRA platform presentations at the SETAC Europe 2011 conference in Milan which can be viewed in full here.
The presentations address key aspects of QSAR models and...