<?xml version="1.0" encoding="UTF-8"?><xml><records><record><source-app name="Biblio" version="6.x">Drupal-Biblio</source-app><ref-type>17</ref-type><contributors><authors><author><style face="normal" font="default" size="100%">Benfenati, Emilio</style></author><author><style face="normal" font="default" size="100%">Diaza, Rodolfo Gonella</style></author><author><style face="normal" font="default" size="100%">Cassano, Antonio</style></author><author><style face="normal" font="default" size="100%">Pardoe, Simon</style></author><author><style face="normal" font="default" size="100%">Gini, Giuseppina</style></author><author><style face="normal" font="default" size="100%">Mays, Claire</style></author><author><style face="normal" font="default" size="100%">Knauf, Ralf</style></author><author><style face="normal" font="default" size="100%">Benighaus, Ludger</style></author></authors></contributors><titles><title><style face="normal" font="default" size="100%">The acceptance of in silico models for REACH: Requirements, barriers, and perspectives.</style></title><secondary-title><style face="normal" font="default" size="100%">Chemistry Central journal</style></secondary-title><alt-title><style face="normal" font="default" size="100%">Chem Cent J</style></alt-title></titles><keywords><keyword><style  face="normal" font="default" size="100%">Animal Testing Alternatives</style></keyword><keyword><style  face="normal" font="default" size="100%">in-silico models</style></keyword><keyword><style  face="normal" font="default" size="100%">Industry</style></keyword><keyword><style  face="normal" font="default" size="100%">NGOs</style></keyword><keyword><style  face="normal" font="default" size="100%">ORCHESTRA</style></keyword><keyword><style  face="normal" font="default" size="100%">REACH</style></keyword><keyword><style  face="normal" font="default" size="100%">Regulators</style></keyword></keywords><dates><year><style  face="normal" font="default" size="100%">2011</style></year><pub-dates><date><style  face="normal" font="default" size="100%">2011</style></date></pub-dates></dates><volume><style face="normal" font="default" size="100%">5</style></volume><pages><style face="normal" font="default" size="100%">58</style></pages><language><style face="normal" font="default" size="100%">eng</style></language><abstract><style face="normal" font="default" size="100%">ABSTRACT: In silico models have prompted considerable interest and debate because of their potential value in predicting the properties of chemical substances for regulatory purposes. The European REACH legislation promotes innovation and encourages the use of alternative methods, but in practice the use of in silico models is still very limited. There are many stakeholders influencing the regulatory trajectory of quantitative structure-activity relationships (QSAR) models, including regulators, industry, model developers and consultants. Here we outline some of the issues and challenges involved in the acceptance of these methods for regulatory purposes.</style></abstract><custom1><style face="normal" font="default" size="100%">http://www.ncbi.nlm.nih.gov/pubmed/21982269?dopt=Abstract</style></custom1></record></records></xml>