The documentary 'QSARs in REACH?' is based on interviews with regulators, industry and QSAR developers, and addresses some of the key issues and priorities in the further use of QSARs within REACH.
The documentary was first shown at the ORCHESTRA booth at the 2011 SETAC Europe conference in Milan. Here it can be viewed online in 4 short separate sections. The 20+ contributors are listed below and at the end of the final section, with our thanks to them.
QSARs have been used for decades in the development of pharmaceuticals, where a drug is to be developed to achieve a particular biological action. Our interest here is in the reverse use, where the chemical is known, and the biological action is to be predicted. That too has been the focus of research for decades. But here we are concerned specifically with their use for evaluating toxicity within the regulatory framework of REACH, and it is early days.
In practice, the use of in silico methods by European industry within REACH is still limited. There are three key practical issues that can delay their use. They are highly inter-connected.