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Report of the Delphi Experts Workshop

Submitted by admin on Mon, 2012-06-25 19:12

Document Subject:

Successful Communication of scientific Content on the Example of testing Chemical Substances - Summary of Results
December 2011
Stuttgart, Germany

Document:

group-delphi-communication-orchestra-results-english-version.pdf

Document:

group-delphi-communication-orchestra-results-german-version.pdf

(Available in English and German)

Video Documentary - Introduction & Regulatory perspectives

Introduction (1 min) & Regulatory perspectives (8 mins)

Interviews with regulators, including ECHA and national regulators on how they see the role and potential of QSAR models within REACH.

CAESAR

CAESAR is an EC funded project specifically dedicated to develop QSAR models for the REACH legislation. Models for five endpoints have been developed:

ORCHESTRA Workshop: REACH and QSAR - What can we learn from case studies?

orchestra workshop banner

••• NEW: The workshop and course outcomes

Goals and Agenda

Draft Version of the Agenda:
(Version 27 January 2010)

Time and Venue

DATABASES

Several toxicity databases are available. They address different endpoints, chemicals, and have different format. Check should be done if the collection of data has been curated.

The DSSTox database gather a series of collections of curated datasets:

ISSCAN
AMBIT

In Silico Software and Resources

Many QSAR models have been developed and some are publicly available. Depending on the purpose different models should be used. For instance, for REACH certain requirements have been defined (link to above). For regulatory purposes transparency is highly preferred, in order to provide full information on the model. This also complies with the OECD principles (link). As a consequence, the user should verify if full details on the model are available. For commercial models there may be limitations.

These are some examples of publicly available models developed within the EC projects evaluated within ORCHESTRA.

A short technical survey - for those involved in toxicology

Benefits and barriers to the use of computer-based methods: Online Survey and Report

Questionnaire image In recent years the EU have funded research into developing QSAR / In Silico (i.e. computer-based) methods for the evaluation of chemical toxicity. This project is intended to communicate those findings so that the research is used more widely. The online survey will help us to find out what information is needed.