The documentary 'QSARs in REACH?' is based on interviews with regulators, industry and QSAR developers, and addresses some of the key issues and priorities in the further use of QSARs within REACH.
The documentary was first shown at the ORCHESTRA booth at the 2011 SETAC Europe conference in Milan. Here it can be viewed online in 4 short separate sections. The 20+ contributors are listed below and at the end of the final section, with our thanks to them.
The five ORCHESTRA platform presentations at the SETAC Europe 2011 conference in Milan can now be viewed in full below. The presentations address key aspects of QSAR models and their regulatory use.
Videos include: PowerPoint slides + speaker + event images + Q&A session.
How to improve the safe use, explanation and acceptance of QSAR models for REACH?
Emilio Benfenati (18 mins)
Interviews with QSAR developers on the value and limits of QSAR models, to offer an understanding of the core issues of what makes a good QSAR model, the importance of using models appropriately, and how to review or question the outputs.
The CAESAR and VEGA platforms have been produced from EC-funded research, and are therefore freely available for use. The software can be downloaded. Furthermore, predicted values for more than four million chemicals will be made freely available.
ECHA does not intend to produce a list of ‘approved’ models, because the value of a model depends on how it is used. (See FAQ: ‘What makes a good QSAR model?’) Every user of QSARs needs to be aware that QSAR models are only appropriate and reliable for specific sets of chemicals. A highly reliable model will not produce reliable results for chemicals that lie outside the domain of applicability. In addition, models may be suitable for different regulatory functions: risk assessment, classification and labelling or prioritisation, because each makes different demands on the model.