NGOs

Report of our online technical stakeholder survey

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The report of our online stakeholder survey is available here. Learn about benefits and barriers to QSARs use according to specialists, regulators and industry.

The results of this survey have been published in the open access literature as follow:

Mays C, Benfenati E and Pardoe S.
Use and perceived benefits and barriers of QSAR models for REACH: findings from a questionnaire to stakeholders
Chemistry Central Journal 2012, 6:159 doi:10.1186/1752-153X-6-159

http://journal.chemistrycentral.com/content/6/1/159

Video Documentary: QSARs in REACH? - Uses, issues and priorities

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The documentary 'QSARs in REACH?' is based on interviews with regulators, industry and QSAR developers, and addresses some of the key issues and priorities in the further use of QSARs within REACH. 

The documentary was first shown at the ORCHESTRA booth at the 2011 SETAC Europe conference in Milan.   Here it can be viewed online in 4 short separate sections.  The 20+ contributors are listed below and at the end of the final section, with our thanks to them.

 

Usage of in-silico

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7 reasons to use in-silico methods

1. Cost and feasibility

The REACH legislation requires industry to evaluate the toxicity not just of new chemicals, but also of the tens of thousands of existing chemical substances that are currently in use but have never been subject to regulatory testing.  Many argue that to achieve this by traditional in vivo testing would take decades, cost billions and consume many millions of vertebrates.  In addition to the time and costs for industry, there is a lack of laboratories in Europe capable of performing in vivo tests for such large numbers of substances.

Policy issues around computer-based methods as alternatives to animal testing

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Questionnaire imageThe short questionnaire is our invitation to policy makers, industry managers, educators, political leaders, NGOs, investors, citizens and all others who are not specialists in toxicology to comment on some of the issues that are raised and/or addressed by computer-based (in silico) methods.

We really hope you can take a few minutes to complete it.  Please also email the link to others who may be interested.

 

 

Improving realistic use of in silico methods

Submitted by rgdiaza on Fri, 2013-02-15 16:56
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Document Subject: 

The ORCHESTRA layman's report, entitled "Improving realistic use of in silico methods", gives an overview of the most significant resources developed by ORCHESTRA for people involved or interested in the use of in silico methods in REACH.

Each resource is briefly explained and the readers are provided with links or information about where they can download it or find more about it. This report has been developed with users’ needs in mind and together with the ORCHESTRA website, the introductive leaflet and the e-book is an important source of information.

Document: 
application/pdf iconorchestra-laymanreport.pdf

Workshop Posters at: REACH and QSAR - What can we learn from case studies?

Submitted by admin on Wed, 2011-12-07 16:31
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Workshop Posters at: REACH and QSAR: What can we learn from case studies - image
Document Subject: 

Presented at Workshop: REACH and QSAR: What can we learn from case studies? (Mario Negri Institute – Milano (Italy) April 6th 2011)
(Morning session)

Document: 
application/pdf iconPoster 1 - ORCHESTRA - In Silico methods: What is available? Who is interested? How to promote?
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application/pdf iconPoster 2 - CAESAR - Five open source QSAR models for REACH
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application/pdf iconPoster 3 - DEMETRA - Development of Environmental Modules for Evaluation of Toxicity of pesticide Residues in Agriculture
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application/pdf iconPoster 4 - CHEMOMENTUM - An innovative GRID-based platform to develop computer-based predictive models for toxicology assessment
Document: 
application/pdf iconPoster 5 - RAINBOW, SCARLET & OSIRIS - In Silico Approaches in Toxicology: from Alternative to Integrative
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application/pdf iconPoster 6 - ANTARES - Alternative Non-Testing methods Assessed for REACH Substances
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application/pdf iconPoster 7 - OSIRIS: Development of a Webtool for Integrated Testing Strategies within REACH
Document: 
application/pdf iconPoster 8 - VEGA - A QSAR Platform for REACH
Document: 
application/pdf iconPoster 9 - VEGA - A Candidate Applicability Domain Index
Document: 
application/pdf iconPoster 10 - The Bioconcentration Factor (BCF) Prediction and New Features incorporated in VEGA
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application/pdf iconPoster 11 - Computational Approaches for Assessment of Toxicity: Applying Data Mining to the Discovery of New Structural Alerts
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application/pdf iconPoster 12 - Use and Comparison of In Silico Models to estimate Carcinogenicity
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application/pdf iconPoster 13 - QSAR Modeling of Toxicity of Mixtures by CORAL Software
Document: 
application/pdf iconPoster 14 - QSAR Modeling of Cytotoxicity of Nanoparticles

More information about the workshop and the outcomes here

Newsletter, Issue 1, June 2010

Submitted by admin on Wed, 2011-11-23 20:59
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Newsletter, Issue 1, June 2010 Image
Document Subject: 

New Website
Dissemination Strategies
and Workshop

Document: 
application/pdf iconorchestra1st-newsletterjune2010.pdf

Newsletter, Issue 1, June 2010

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In silico methods newsletter issue 1 - June 2010

New Website
Dissemination Strategies
and Workshop

 

Are QSAR models expensive, or free to use?

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The CAESAR and VEGA platforms have been produced from EC-funded research, and are therefore freely available for use.  The software can be downloaded. Furthermore, predicted values for more than four million chemicals will be made freely available.

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