Pharmaceuticals

Report of our online technical stakeholder survey

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The report of our online stakeholder survey is available here. Learn about benefits and barriers to QSARs use according to specialists, regulators and industry.

The results of this survey have been published in the open access literature as follow:

Mays C, Benfenati E and Pardoe S.
Use and perceived benefits and barriers of QSAR models for REACH: findings from a questionnaire to stakeholders
Chemistry Central Journal 2012, 6:159 doi:10.1186/1752-153X-6-159

http://journal.chemistrycentral.com/content/6/1/159

COURSE ON IN-SILICO METHODS AND WORKSHOP ON REACH AND QSAR

Orchestra Banner for Workshop and Course
Date: 
Wed, 2011-04-06 00 - Thu, 2011-04-07 00

••• NEW: The workshop and course outcomes

Course on in-silico methods

Mario Negri Institute, Milan, Italy

7 April 2011

We have reached the limit of subscriptions to the course planned for April 5th. The course will be repeated on April 7th.

Usage of in-silico

7 reasons to use in-silico methods

1. Cost and feasibility

The REACH legislation requires industry to evaluate the toxicity not just of new chemicals, but also of the tens of thousands of existing chemical substances that are currently in use but have never been subject to regulatory testing.  Many argue that to achieve this by traditional in vivo testing would take decades, cost billions and consume many millions of vertebrates.  In addition to the time and costs for industry, there is a lack of laboratories in Europe capable of performing in vivo tests for such large numbers of substances.

Policy issues around computer-based methods as alternatives to animal testing

 

Questionnaire imageThe short questionnaire is our invitation to policy makers, industry managers, educators, political leaders, NGOs, investors, citizens and all others who are not specialists in toxicology to comment on some of the issues that are raised and/or addressed by computer-based (in silico) methods.

We really hope you can take a few minutes to complete it.  Please also email the link to others who may be interested.

 

 

Improving realistic use of in silico methods

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Document Subject: 

The ORCHESTRA layman's report, entitled "Improving realistic use of in silico methods", gives an overview of the most significant resources developed by ORCHESTRA for people involved or interested in the use of in silico methods in REACH.

Each resource is briefly explained and the readers are provided with links or information about where they can download it or find more about it. This report has been developed with users’ needs in mind and together with the ORCHESTRA website, the introductive leaflet and the e-book is an important source of information.

ORCHESTRA e-book “theory, guidance and applications on QSAR and REACH”

Document Subject: 

Main target of this e-book are the chemical industry and regulators, which have to deal with the REACH regulation.

 

The e-book "Theory, guidance and applications on QSAR and REACH" has been developed with the aim of providing an accessible source of information about in silico models and their use in toxicology for regulatory purposes.

 

Content:

Video Documentary: QSARs in REACH? - Uses, issues and priorities

A video documentary in four parts, based on interviews
with regulators, industry and QSAR developers.

Please respond to one of our surveys

The use of "in silico methods"

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1. Technical survey for those involved in toxicology

Complete it online  /  Read more..

2. Non-technical survey for citizens, policy makers, industry managers, educators, political leaders, NGOs, investors and others

Introductory leaflet on in-silico methods

The leaflet is intended as a concise and accessible explanation of in silico methods, and the issues around them, for people who want to know about them, and/or what to understand what the ORCHESTRA project is about.

In silico methods leaflet

The leaflet is available in English, French, German and Italian languages.

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